Aside from extremely rare pieces of armor and weapons, there are a ton of other items that you can get your hands on.
For more help on Fallout 4, read our Fusion Cores Locations, Mini Nukes Locations, Scrap Farming Resources and How to Build Settlements.
Fallout 4 Unique Items Locations
Fallout 4 Unique items include your very own home and a number of other things which might come in handy — there’s nothing useless in post-apocalyptic world!
With the exception of Unique Weapons and Unique Armor, this guide contains the locations of every rare item that you can gather in Fallout 4:
Artillery Schematic
Location: Neighborhood; South Boston, the Castle
Threat Level: 35+
You’ll find Artillery Schematic inside The Castle’s tunnels during The Minutemen Quest: Old Guns.
Drugged Water
Location: Neighborhood; Esplanade, HalluciGen, Inc.
Threat Level: 15-20
You need to head inside HalluciGen, Inc. in Neighborhood; Esplanade to find this unique item.
Experimental Serum
Location: Quincy and Southern Commonwealth, the Institute
Threat Level: 30+
You need to head inside FEV Laboratory during Miscellaneous Quest: Virgil’s Cure to find this unique item inside.
Food Paste
Location: Quincy and Southern Commonwealth, Suffolk County Charter School
Threat Level: 40+
You need to head over to the said location in order to find this unique item all around the area
Giddyup Buttercup Parts
Location: Quincy and Southern Commonwealth, Wilson Atomatoys Factory
Threat Level: 40+
You need to head inside a small store room using a Wilson Atomatoys ID Card during Miscellaneous Quest: Arlen Glass in order to find this unique item.
HalluciGen Gas Canister
Location: Neighborhood; Esplanade, HalluciGen, Inc.
Threat Level: 15-20
You need to head over to the basement laboratory at the said location in order to find this unique item.
Home Plate
Location: Neighborhood; the Fens, Home Plate
You can purchase this unique item for 2,000 Caps at the Mayor’s Office.
Homing Beacons
Location: Neighborhood; Boston Harbor [Waterfront], Yangtze
Threat Level: 30+
You need to finish the optional mission, Here There Be Monsters, in order to acquire this unique item as a reward.
Institute Beacon
Location: Quincy and Southern Commonwealth, the Institute
Threat Level: 30+
You need to finish the Institute Quest: Airship Down in order to acquire this unique item.
Mysterious Serum
Location: North Central Commonwealth, Parsons State Insane Asylum
Threat Level: 35+
You need to finish the optional mission, The Secret of Cabot House, in order to acquire this unique item as a reward.
Pickman’s Blade
Location: Neighborhood; North End, Pickman Gallery
Threat Level: 20+
You simply need to side with Pickman in order to acquire this unique item as a reward.
Prevent
Location: North Central Commonwealth, Med-Tek Research
Threat Level: 25+
You’ll stumble upon this unique item at the sub-level laboratory during Long Road Ahead companion mission.
Railroad Stealth Boy
Location: Neighborhood; North End, Old North Church
Threat Level: 25+
You need to finish the Railroad Quest: Memory Interrupted in order to acquire this unique item as a reward.
Signed Baseball
Location: Quincy and Southern Commonwealth, Westing Estate
Threat Level: 15-25
You can find this unique item at the said location and sell it to Moe Cronin at Swatters in Diamond City.
Signed Baseball Card
Location: Quincy and Southern Commonwealth, Westing Estate
Threat Level: 15-25
You can find this unique item at the said location and sell it to Moe Cronin at Swatters in Diamond City.
Signed Catcher’s Mitt
Location: Quincy and Southern Commonwealth, Westing Estate
Threat Level: 15-25
You can find this unique item at the said location and sell it to Moe Cronin at Swatters in Diamond City.
Silver Shroud Photo
Location: Neighborhood; Back Bay, Hubris Comics
Threat Level: 15-25
You simply need to head inside the store and find the unique item in the said location.
Silver Submachine Gun Prop
Location: Neighborhood; Back Bay, Hubris Comics
Threat Level: 15-25
You need to head over to the fourth floor and find the unique item sitting on a crate behind the TV.
Silver Shroud Script
Location: Neighborhood; Back Bay, Hubris Comics
Threat Level: 15-25
You need to head over to the third floor and find the unique item inside the locked office.
Slocum’s BuzzBites Recipe
Location: North Central Commonwealth, Slocum’s Joe Corporate HQ
Threat Level: 20+
You need to check the safe located in the said location in order to find the unique item.
The Gilded Grasshopper
Location: Neighborhood; Financial District, Faneuil Hall
Threat Level: 20+
You need to head over to rooftop of the said structure in order to find the unique item.
Toy Buttercup
Location: North Central Commonwealth, the Slog
Threat Level: 35+
You need to finish the miscellaneous mission, Arlen Glass, in order to acquire this unique item as a reward.
Vault Room
Location: Western Commonwealth, Vault 81
Threat Level: 15-25
You need to finish the optional mission, Hole in the Wall, in order to acquire this unique item as a reward.
Wazer Wifle
Location: Quincy and Southern Commonwealth, the Institute
Threat Level: 30+
You need to finish the Shaun’s three missions after the Main and Faction missions in order to acquire this unique item as a reward.
Brotherhood of Steel House
Location: Coastal Commonwealth, Prydwen
Threat Level: 30+
You need to finish the Brotherhood of Steel mission, Tour of Duty, in order to acquire this unique item as a reward.
Institute House
Location: Coastal Commonwealth, Prydwen
Threat Level: 30+
You need to finish the Institute Quest mission, Synth Retention, in order to acquire this unique item as a reward.
Found anything missing or confusing? Let us know in the comments section below!
