The point of no return is basically a point in the storyline where you are forced to complete the main story before returning to do anything else.
God of War: Ragnarok features a ton of collectibles and side activities, as well as many realms to explore. Hence, you might want to know if the game has a point of no return so that you can loot as many items and gear for Kratos as possible beforehand.
Is there a point of no return in God of War: Ragnarok?
Thankfully no. After completing the main storyline, you can always go back to the game. So, there is no point of no return in the God of War: Ragnarok.
Can you do side quests after beating God of War: Ragnarok?
You can always come back for the missed missions, quests, and side quests (favors) to collect the collectibles as well as earn the remaining trophies for the game you have missed after completing the main storyline.
What this means is, you do not have to rush to discover all of the realms and quests. You can miss or skip parts of the game and come back for them when you wish to.
When you complete the main storyline, you can always unlock new content which is necessarily post-storyline content. You would face some very powerful bosses in this mode.
In fact, it is recommended that you leave a big chunk of the side content till after finishing the main story of GoW Ragnarok. Not only are there spoiler-related reasons for it but also a lot of things are locked until you finish the main game so best to finish it quickly and then tackle them.