From what we have seen of Mafia 3, it appears like drive-by shooting is going to a skill in the game.
Speaking about car chases and drive-by shooting with Examiner, the game’s creative director, Haden Blackman talked about the challenges being offered in the game:
We always want to be providing you with skill checks in the game. I think that’s a fun element in a game and for me, it’s that combination of challenge and choice. It’s hard to have fun with a game if you’re not being challenged. you want to have something to overcome, but then you want to have choice with how you do that.
However, when it comes to vehicles, the developer did not want the shooting to be challenging, but the driving mechanics, a lot of which is done by smart targeting:
In the case of vehicles, we said ‘okay we’ve got the cover-shooting and are providing you with gun challenges constantly through the game and through that.’ In the driving, we don’t want the shooting to necessarily be the challenge. We want the driving to be the challenge, so a lot of that is done through smart targeting.
Mafia 3 is scheduled to release sometime in 2016 for PC, Xbox One, and Playstation 4.